This is an ideal once-a-day delivery system for drugs that are otherwise absorbed only from the stomach or intestine. upper part of the gastrointestinal tract, or may have a low solubility in intestinal fluid. However, since most drugs would transit the stomach rather quickly, it is difficult to make these into long acting or controlled release formulations.
Longer retention in stomach improves drug absorption.
The tablet can be designed to offer a combination of instant and sustained drug release profiles, and since it is once-a-day, it improves patient compliance.
Based on GRID, Baclofen GRS, a once-a-day capsule to treat muscle spasticity, has been launched in India.
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